منابع مشابه
ATP synthase
All living species use ATP as a general source of energy by hydrolysing it into ADP and phosphate. In most species the regeneration of this vital molecule is catalysed by the H+-transporting F1F0 ATP synthases, marvellous machines that couple the flow of protons down an electrochemical gradient to form ATP from ADP and phosphate. Under certain circumstances these enzymes can also work in the re...
متن کاملQuick guide: ATP synthase
denotes the soluble catalytic headgroup where ATP synthesis and hydrolysis occur, and F o is the ion-translocating membrane domain (see Figure). What is it? An enzyme that uses energy from the transmembrane proton electrochemical gradient, generated by oxidative metabolism or photosynthesis, to produce ATP from ADP and P i. The enzyme can also act in reverse, hydrolysing ATP and pumping H + or ...
متن کاملWinding and unwinding ATP synthase
ell migration depends on polarized actin polymerization at a cell's front edge. To get the most out of these actin networks, plasma membrane flexibility must be similarly polarized, according to results from Amit Vasanji, Paul Fox (Cleveland Clinic Foundation, Cleveland, OH), and colleagues. The group shows that the membrane is stiffest at the front of migrating endothelial cells. This oriented...
متن کاملImpaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene.
Mutations in human mitochondrial DNA are a well recognized cause of disease. A mutation at nucleotide position 8993 of human mitochondrial DNA, located within the gene for ATP synthase subunit 6, is associated with the neurological muscle weakness, ataxia, and retinitis pigmentosa (NARP) syndrome. To enable analysis of this mutation in control nuclear backgrounds, two different cell lines were ...
متن کاملATP synthesis driven by proton transport in F1F0-ATP synthase.
Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers ke...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.51.32546